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Indophagolin

CAS No. 1207660-00-1

Indophagolin( —— )

Catalog No. M23377 CAS No. 1207660-00-1

Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Indophagolin
  • Note
    Research use only, not for human use.
  • Brief Description
    Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM.?
  • Description
    Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM.?Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
  • In Vitro
    Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    autophagy|P2X1|P2X3|P2X4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1207660-00-1
  • Formula Weight
    523.75
  • Molecular Formula
    C19H15BrClF3N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1.
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