Indometacin ( Indomethacin; Indometacin; Indocin )

Catalog No. M14921 CAS No. 53-86-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Indometacin
Note

Research use only, not for human use.
Brief Description

Indomethacin is a non-steroidal antiinflammatory agent (NSAIA) with antiinflammatory, analgesic and antipyretic activity.
Description

Indomethacin is a non-steroidal antiinflammatory agent (NSAIA) with antiinflammatory, analgesic and antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway.
Synonyms

Indomethacin; Indometacin; Indocin
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX-1; COX-1; COX-2; PDE2; PLA2
Research Area

Inflammation/Immunology
Indication

——

CAS Number

53-86-1
Formula Weight

357.79
Molecular Formula

C19H16ClNO4
Purity

>98%(HPLC)
Solubility

Ethanol: 24 mg/mL (67.07 mM); DMSO: 72 mg/mL (201.23 mM)
SMILES

O=C(O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Chemical Name

2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid

1.Mitchell JA, et al. Proc Natl Acad Sci U S A. 1993, 90(24), 11693-11697.

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