Amentoflavone

Research use only, not for human use.

Amentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9.

Amentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are proteins used for drug metabolism in the body, is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted supression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.

Didemethyl Ginkgetin; NSC 295677

Chromatin/Epigenetic

COX

COX; COX-2; κ-opioid receptor; CYP2C9; CYP3A4; PLA2

Other Indications

——

1617-53-4

538.46

C30H18O10

>98%(HPLC)

Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone

O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=CC(C5=CC(C6=C(O5)C=C(O)C=C6O)=O)=CC=C4O

8-[5-(5,7-Dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years