Icaritin
CAS No. 118525-40-9
Icaritin ( Icaritin )
Catalog No. M17860 CAS No. 118525-40-9
Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 57 | In Stock |
|
10MG | 105 | In Stock |
|
25MG | 177 | In Stock |
|
50MG | 264 | In Stock |
|
100MG | 394 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameIcaritin
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NoteResearch use only, not for human use.
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Brief DescriptionIcaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation.
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DescriptionIcaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.
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SynonymsIcaritin
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PathwayOthers
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TargetOther Targets
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RecptorJAK2; STAT3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number118525-40-9
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Formula Weight368.38
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Molecular FormulaC21H20O6
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Purity98%
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SolubilityDMSO : 14 mg/mL 38.00 mM;
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SMILESCC(=CCc1c(cc(c2c1oc(c(c2=O)O)c1ccc(cc1)OC)O)O)C
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Chemical Name3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhu S, et al. Oncotarget. 2015 Apr 30;6(12):10460-72.
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