Icaritin

CAS No. 118525-40-9

Icaritin ( Icaritin )

Catalog No. M17860 CAS No. 118525-40-9

Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 57 In Stock
10MG 105 In Stock
25MG 177 In Stock
50MG 264 In Stock
100MG 394 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Icaritin
  • Note
    Research use only, not for human use.
  • Brief Description
    Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation.
  • Description
    Icaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.
  • Synonyms
    Icaritin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    JAK2; STAT3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    118525-40-9
  • Formula Weight
    368.38
  • Molecular Formula
    C21H20O6
  • Purity
    98%
  • Solubility
    DMSO : 14 mg/mL 38.00 mM;
  • SMILES
    CC(=CCc1c(cc(c2c1oc(c(c2=O)O)c1ccc(cc1)OC)O)O)C
  • Chemical Name
    3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhu S, et al. Oncotarget. 2015 Apr 30;6(12):10460-72.
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