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Ibodutant
CAS No. 522664-63-7
Ibodutant( MEN-15596 | MEN 15596 )
Catalog No. M14847 CAS No. 522664-63-7
A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIbodutant
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
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DescriptionA potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6); induces a concentration-dependent rightward shift of the [βAla(8)]NKA(4-10) concentration-response curves without depressing the maximal contractile effect (3-100 nM); shows good in vivo activity after intravenous, intraduodenal, and oral administration in guinea pigs.Irritable Bowel Syndrome Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMEN-15596 | MEN 15596
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNeurokinin Receptor
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number522664-63-7
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Formula Weight644.866
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Molecular FormulaC37H48N4O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC2=CC=C(C)C=C2S1)NC3(C(N[C@H](CC4=CC=CC=C4)C(NCC5CCN(CC6CCOCC6)CC5)=O)=O)CCCC3
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Chemical Name6-methyl-N-(1-(((R)-1-oxo-3-phenyl-1-(((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)amino)propan-2-yl)carbamoyl)cyclopentyl)-2,3-dihydrobenzo[b]thiophene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meini S, et al. J Pharmacol Exp Ther. 2009 May;329(2):486-95.
2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807.
3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.
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