Iberin

CAS No. 505-44-2

Iberin( NSC 321801 )

Catalog No. M14724 CAS No. 505-44-2

Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 122 Get Quote
10MG 178 Get Quote
25MG 295 Get Quote
50MG 442 Get Quote
100MG 644 Get Quote
500MG 1332 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Iberin
  • Note
    Research use only, not for human use.
  • Brief Description
    Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity.
  • Description
    Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity, a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa, and significantly induces Nrf2 nuclear translocation in NIH3T3 fibroblasts; induces cell cycle arrest and apoptosis in human neuroblastoma cells associated with inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins.
  • In Vitro
    Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.
  • In Vivo
    Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.
  • Synonyms
    NSC 321801
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    505-44-2
  • Formula Weight
    163.26106
  • Molecular Formula
    C5H9NOS2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 10 mg/mL
  • SMILES
    S=C=NCCCS(C)=O
  • Chemical Name
    Propane, 1-isothiocyanato-3-(methylsulfinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jadhav U, et al. Int J Mol Med. 2007 Mar;19(3):353-61. 2. Jadhav U, et al. J Pharmacol Sci. 2007 Feb;103(2):247-51. 3. Jakobsen TH, et al. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. 4. Tan SY, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6648-59.
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