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JHU395
CAS No. 2079938-92-2
JHU395( —— )
Catalog No. M32972 CAS No. 2079938-92-2
JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 93 | Get Quote |
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| 5MG | 140 | Get Quote |
|
| 10MG | 242 | Get Quote |
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| 25MG | 449 | Get Quote |
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| 50MG | 701 | Get Quote |
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| 100MG | 1044 | Get Quote |
|
| 200MG | 1404 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJHU395
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NoteResearch use only, not for human use.
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Brief DescriptionJHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON).
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DescriptionJHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2079938-92-2
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Formula Weight447.48
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Molecular FormulaC22H29N3O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (223.47 mM; Ultrasonic )
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SMILESC(OC(C(C)(C)C)=O)(OC(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)C1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lemberg KM, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheralnerve sheath tumor. Mol Cancer Ther. 2019 Oct 8. pii: molcanther.0319.2019.?
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