ISO-1 ( ISO-1; ISO 1; ISO1; MIF Antagonist )

Catalog No. M17520 CAS No. 478336-92-4

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Product Name

ISO-1
Note

Research use only, not for human use.
Brief Description

ISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
Description

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.
Synonyms

ISO-1; ISO 1; ISO1; MIF Antagonist
Pathway

Others
Target

Other Targets
Recptor

MIF
Research Area

Inflammation/Immunology
Indication

——

CAS Number

478336-92-4
Formula Weight

235.2
Molecular Formula

C12H13NO4
Purity

98%
Solubility

DMSO : ≥ 36 mg/mL; 153.04 mM
SMILES

COC(=O)CC1CC(=NO1)c1ccc(O)cc1
Chemical Name

4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester

1. Xu L, et al. Drug Discov Today. 2013 Jun;18(11-12):592-600.

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