ISO-1

Research use only, not for human use.

ISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.

ISO-1 (0.1-20 μM; 16 hours) has a slight inhibitory effect on Cox-2 secretion without the addition of recombinant MIF. Western Blot Analysis Cell Line:RAW 264.7 macrophage cells Concentration: 0.1μM， 1μM，10μM，20μM Incubation Time:16 hours Result:SuppressedCox-2 secretion.

ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect.ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants. Animal Model: C57Bl/6 MIF+/+ and MIF–/– mice Dosage:3.5-35 mg/kg Administration:Injected intraperitoneally; 3.5-35 mg/kg; twice a day ; 2 weeks Result:Was protective against lethal sepsis.Animal Model:Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice Dosage:35 mg/kg Administration:Intraperitoneal injection; 35 mg/kg; twice daily; 3 daysResult:Reduced average endometriotic implant size.

ISO-1 | ISO 1 | ISO1 | MIF Antagonist

Others

Other Targets

MIF

Inflammation/Immunology

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478336-92-4

235.2

C12H13NO4

>98% (HPLC)

DMSO : ≥ 36 mg/mL; 153.04 mM

COC(=O)CC1CC(=NO1)c1ccc(O)cc1

4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester

(-20℃)

With Ice Pack

≥ 2 years