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IQ3
CAS No. 312538-03-7
IQ3( —— )
Catalog No. M22014 CAS No. 312538-03-7
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | Get Quote |
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| 10MG | 105 | Get Quote |
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| 25MG | 208 | Get Quote |
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| 50MG | 332 | Get Quote |
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| 100MG | 494 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIQ3
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NoteResearch use only, not for human use.
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Brief DescriptionIQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).
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DescriptionIQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
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In VitroIQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively.IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3. Cell Viability Assay Cell Line:PBMCs.Concentration:0-80 μM (200 ng/mL LPS).Incubation Time:30 min.Result:Downregulated TNF-α concentration (IC50 = 4.7 μM).
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorJNK3|JNK1|JNK2
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Research Area——
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Indication——
Chemical Information
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CAS Number312538-03-7
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Formula Weight341.32
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Molecular FormulaC20H11N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (73.25 mM)
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SMILESO=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Schepetkin I A , Kirpotina L N , Khlebnikov A I , et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.
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