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INDY
CAS No. 1169755-45-6
INDY ( -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one )
Catalog No. M26718 CAS No. 1169755-45-6
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | Get Quote |
|
| 10MG | 66 | Get Quote |
|
| 25MG | 102 | Get Quote |
|
| 50MG | 145 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameINDY
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NoteResearch use only, not for human use.
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Brief DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
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DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
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Synonyms-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
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PathwayOthers
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TargetOther Targets
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RecptorGluN1; NMDA receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1169755-45-6
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Formula Weight235.3
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Molecular FormulaC12H13NO2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Issberner JP, Sillar KT. The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64.
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