Cart
sales@molnova.com
INDY
CAS No. 1169755-45-6
INDY ( -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one )
Catalog No. M26718 CAS No. 1169755-45-6
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | Get Quote |
|
| 10MG | 66 | Get Quote |
|
| 25MG | 102 | Get Quote |
|
| 50MG | 145 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameINDY
-
NoteResearch use only, not for human use.
-
Brief DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
-
DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
-
Synonyms-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
-
PathwayOthers
-
TargetOther Targets
-
RecptorGluN1; NMDA receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1169755-45-6
-
Formula Weight235.3
-
Molecular FormulaC12H13NO2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Issberner JP, Sillar KT. The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64.
molnova catalog
related products
-
Naringenin chalcone
Naringenin chalcone is a product natural isolated from stems of Machaerium isadelphum (Fabaceae).
-
Alpha-Angelica Lacto...
Alpha-Angelica Lactone has cardiotonic activity may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.?
-
Salifungin
Detail unknown.
