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INDY

CAS No. 1169755-45-6

INDY ( -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one )

Catalog No. M26718 CAS No. 1169755-45-6

INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    INDY
  • Note
    Research use only, not for human use.
  • Brief Description
    INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
  • Description
    INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
  • Synonyms
    -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GluN1; NMDA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1169755-45-6
  • Formula Weight
    235.3
  • Molecular Formula
    C12H13NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Issberner JP, Sillar KT. The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64.
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