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Jervine
CAS No. 469-59-0
Jervine ( 11-Ketocyclopamine )
Catalog No. M17515 CAS No. 469-59-0
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 246 | In Stock |
|
| 50MG | 473 | In Stock |
|
| 100MG | 678 | In Stock |
|
| 500MG | 1368 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJervine
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NoteResearch use only, not for human use.
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Brief DescriptionThe biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.
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DescriptionThe biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
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Synonyms11-Ketocyclopamine
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PathwayOthers
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TargetOther Targets
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RecptorHedgehog; Smoothened
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number469-59-0
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Formula Weight425.61
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Molecular FormulaC27H39NO3
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Purity98%
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SolubilityDMSO : 1 mg/mL2.35 mM;
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SMILESO=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen JK, et al. Genes Dev. 2002 Nov 1; 16(21): 2743–2748.
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