Jervine

Research use only, not for human use.

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis. Western Blot Analysis Cell Line:HEL and TF1a cells Concentration:40 μM Incubation Time:6, 12 and 24 hours Result:Inhibited Akt phosphorylation.

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. Animal Model:Male Sprague Dawley rats (180-200? g)Dosage:50, 100, 200 and 400? mg/kg Administration:Orally Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

11-Ketocyclopamine

Others

Other Targets

Hedgehog| Smoothened

Cancer

——

469-59-0

425.61

C27H39NO3

>98% (HPLC)

DMSO : 1 mg/mL2.35 mM;

O=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C

——

(-20℃)

With Ice Pack

≥ 2 years