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INCA-6
CAS No. 3519-82-2
INCA-6 ( Triptycene-1,4-quinone )
Catalog No. M27468 CAS No. 3519-82-2
INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | Get Quote |
|
| 10MG | 77 | Get Quote |
|
| 25MG | 155 | Get Quote |
|
| 50MG | 299 | Get Quote |
|
| 100MG | 509 | Get Quote |
|
| 500MG | 1107 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameINCA-6
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NoteResearch use only, not for human use.
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Brief DescriptionINCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.
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DescriptionINCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.(In Vitro):In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin.(In Vivo):INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner.
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SynonymsTriptycene-1,4-quinone
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PathwayOthers
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TargetOther Targets
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Recptorprostaglandin F2α
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Research Area——
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Indication——
Chemical Information
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CAS Number3519-82-2
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Formula Weight284.3
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Molecular FormulaC20H12O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=CC(=O)C2=C1C3C=4C=CC=CC4C2C=5C=CC=CC53
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Baryla M, et al. Prostaglandin F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29.
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