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INCA-6

CAS No. 3519-82-2

INCA-6 ( Triptycene-1,4-quinone )

Catalog No. M27468 CAS No. 3519-82-2

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    INCA-6
  • Note
    Research use only, not for human use.
  • Brief Description
    INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.
  • Description
    INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.(In Vitro):In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin.(In Vivo):INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner.
  • Synonyms
    Triptycene-1,4-quinone
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    prostaglandin F2α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3519-82-2
  • Formula Weight
    284.3
  • Molecular Formula
    C20H12O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C=CC(=O)C2=C1C3C=4C=CC=CC4C2C=5C=CC=CC53
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Baryla M, et al. Prostaglandin F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29.
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