INCA-6

Research use only, not for human use.

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.(In Vitro):In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin.(In Vivo):INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner.

Triptycene-1,4-quinone

Others

Other Targets

prostaglandin F2α

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3519-82-2

284.3

C20H12O2

>98% (HPLC)

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O=C1C=CC(=O)C2=C1C3C=4C=CC=CC4C2C=5C=CC=CC53

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(-20℃)

With Ice Pack

≥ 2 years