INCA-6

CAS No. 3519-82-2

INCA-6 ( Triptycene-1,4-quinone )

Catalog No. M27468 CAS No. 3519-82-2

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 45 Get Quote
10MG 77 Get Quote
25MG 155 Get Quote
50MG 299 Get Quote
100MG 509 Get Quote
500MG 1107 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    INCA-6
  • Note
    Research use only, not for human use.
  • Brief Description
    INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.
  • Description
    INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.(In Vitro):In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin.(In Vivo):INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner.
  • Synonyms
    Triptycene-1,4-quinone
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    prostaglandin F2α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3519-82-2
  • Formula Weight
    284.3
  • Molecular Formula
    C20H12O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C=CC(=O)C2=C1C3C=4C=CC=CC4C2C=5C=CC=CC53
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Baryla M, et al. Prostaglandin F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29.
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