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IMS2186

CAS No. 1031206-36-6

IMS2186( —— )

Catalog No. M35954 CAS No. 1031206-36-6

IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IMS2186
  • Note
    Research use only, not for human use.
  • Brief Description
    IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.
  • Description
    IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells.
  • In Vitro
    Cell Cycle Analysis Cell Line:Cancer H460 cells Concentration:3 μM, 10 μM Incubation Time:Result:Showed anti-proliferative activity mediated by arresting cell cycle at G2/M.
  • In Vivo
    Animal Model:Rat model of laser induced CNV Dosage:100 μg/eye, 2.0 μL of the solution of 50 μg/μL Administration:Intravitreal injection; single dose Result:Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1031206-36-6
  • Formula Weight
    296.32
  • Molecular Formula
    C18H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (224.99 mM; Ultrasonic )
  • SMILES
    COc1ccc(\C=C2/COc3ccc(C)cc3C2=O)cc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Falkenstein IA, et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul;33(7):599-609.?
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