IMM-01

Research use only, not for human use.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics.

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Others

Other Targets

CYP3A4;Calcium Channel;P-gp

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218795-74-5

267.4

C12H17N3O2S

>98% (HPLC)

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CC(C)(C)NC(=S)N\N=C\c1ccc(O)cc1O

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(-20℃)

With Ice Pack

≥ 2 years