IM156

CAS No. 1422365-93-2

IM156 ( —— )

Catalog No. M22096 CAS No. 1422365-93-2

IM156 is an orally bioavailable mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 68 Get Quote
10MG 110 Get Quote
25MG 178 Get Quote
50MG 335 Get Quote
100MG 560 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    IM156
  • Note
    Research use only, not for human use.
  • Brief Description
    IM156 is an orally bioavailable mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity.
  • Description
    IM156 is an orally bioavailable mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity. IM156, a new metformin derivative, formerly known as HL156A, has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin.?In vivo treatment of IM156 exacerbated the memory differentiation of virus-specific CD8+ T cells, resulting in an increase in short-lived effector cells but decrease in memory precursor effector cells.?Thus, IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    oxidative phosphorylation (OXPHOS)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1422365-93-2
  • Formula Weight
    315.13
  • Molecular Formula
    C13H16F3N5O?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)Oc1ccc(NC(=N)NC(=N)N2CCCC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Son J , Cho Y W , Woo Y J , et al. Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 + T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection[J]. Immune Network, 2019, 19(2).
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