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IDF-11774
CAS No. 1429054-28-3
IDF-11774( IDF 11774 | IDF11774 )
Catalog No. M11810 CAS No. 1429054-28-3
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 102 | In Stock |
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| 10MG | 177 | In Stock |
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| 25MG | 295 | In Stock |
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| 50MG | 440 | In Stock |
|
| 100MG | 642 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIDF-11774
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NoteResearch use only, not for human use.
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Brief DescriptionIDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor.
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DescriptionIDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
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In Vitro——
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In Vivo——
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SynonymsIDF 11774 | IDF11774
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1429054-28-3
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Formula Weight368.521
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Molecular FormulaC23H32N2O2
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Purity>98% (HPLC)
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SolubilityDMSO : 60 mg/mL 162.82 mM
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SMILESO=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2
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Chemical Name2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ban HS, et al. Bioconjug Chem. 2016 Aug 17;27(8):1911-20.
2. Ban HS, et al. Cell Death Dis. 2017 Jun 1;8(6):e2843.
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