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Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - 103D5R

103D5R

CAS No. 773852-25-8

103D5R( —— )

Catalog No. M15924 CAS No. 773852-25-8

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    103D5R
  • Note
    Research use only, not for human use.
  • Brief Description
    103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
  • Description
    103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity; shows cell proliferation under normoxia in LN229 cell with IC50 of 26 uM, markedly decreases HIF-1α protein synthesis induced by hypoxia or cobaltous ions in a dose- and time-dependent manner; inhibits phosphorylation of Akt, SAPK/JNK and Erk1/2, prevents the activation of HIF-1 target genes under hypoxia such as VEGF and Glut-1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF/HIF Prolyl-hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    773852-25-8
  • Formula Weight
    335.407
  • Molecular Formula
    C20H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]-1H-imidazo[4,5-b]pyridine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tan C, et al. Cancer Res. 2005 Jan 15;65(2):605-12. 2. Belozerov VE, et al. Anticancer Drugs. 2005 Oct;16(9):901-9.
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