ICA

Research use only, not for human use.

ICA is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 μM).

ICA is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 μM).(In Vitro):ICA exhibited antiarrhythmic effects. ICA prevented electrically induced runs of atrial fibrillation in the isolated right atrium and induced atrial postrepolarization refractoriness and depolarized RMP. ICA (1-10 μM) was found to slow CV; however, because of a marked prolongation of effective refractory period, the calculated wavelength was increased. Furthermore, at increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrated prominent depression of other sodium channel-dependent parameters. ICA did not inhibit IK,ACh, but at concentrations above 10 μM, ICA use dependently inhibited INa.

N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine

Cell Cycle/DNA Damage

Potassium Channel

Alkyl/ether

——

——

3374-88-7

254.3

C13H10N4S

>98% (HPLC)

——

N(c1nc(cs1)-c1ccccn1)c1ccccn1

——

(-20℃)

With Ice Pack

≥ 2 years