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ICA-121431
CAS No. 313254-51-2
ICA-121431 ( 22-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl )
Catalog No. M20736 CAS No. 313254-51-2
ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7 with little or no activity against human Nav1.5 or Nav1.7 channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 81 | In Stock |
|
| 25MG | 142 | In Stock |
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| 50MG | 239 | In Stock |
|
| 100MG | 358 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameICA-121431
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NoteResearch use only not for human use.
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Brief DescriptionICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7 with little or no activity against human Nav1.5 or Nav1.7 channels.
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DescriptionICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7 with little or no activity against human Nav1.5 or Nav1.7 channels.
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Synonyms22-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNav1.7 channel
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Research Area——
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Indication——
Chemical Information
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CAS Number313254-51-2
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Formula Weight449.55
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Molecular FormulaC23H19N3O3S2
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Purity>98% (HPLC)
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SolubilityDMSO:44 mg/mL (97.88 mM)
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SMILESO=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1
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Chemical Name22-diphenyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Mambalgin 1
Selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases latency of withdrawal response in mouse tail-flick and paw-flick tests. Analgesic.
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λ-Cyhalothrin
lambda-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group.lambda-Cyhalothrin is used to control a wide range of pests in a variety of applications.lambda-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system.
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PF-06305591
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
