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ICA-1

CAS No. 742038-81-9

ICA-1( —— )

Catalog No. M15832 CAS No. 742038-81-9

ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ICA-1
  • Note
    Research use only, not for human use.
  • Brief Description
    ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM.
  • Description
    ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    742038-81-9
  • Formula Weight
    336.241
  • Molecular Formula
    C10H17N4O7P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1C(C(C(C1N2C=NC(=C2N)C(=O)N)O)O)COP(=O)(O)O
  • Chemical Name
    5-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-1H-imidazole-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94. 2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701. 3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
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