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ICA-1
CAS No. 742038-81-9
ICA-1( —— )
Catalog No. M15832 CAS No. 742038-81-9
ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameICA-1
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NoteResearch use only, not for human use.
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Brief DescriptionICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM.
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DescriptionICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number742038-81-9
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Formula Weight336.241
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Molecular FormulaC10H17N4O7P
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Purity>98% (HPLC)
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Solubility——
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SMILESC1C(C(C(C1N2C=NC(=C2N)C(=O)N)O)O)COP(=O)(O)O
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Chemical Name5-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-1H-imidazole-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94.
2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701.
3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
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