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LXS196

CAS No. 1874276-76-2

LXS196( —— )

Catalog No. M20328 CAS No. 1874276-76-2

LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 63 In Stock
5MG 125 In Stock
10MG 178 In Stock
25MG 332 In Stock
50MG 494 In Stock
100MG 710 In Stock
500MG 1467 In Stock
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Biological Information

  • Product Name
    LXS196
  • Note
    Research use only, not for human use.
  • Brief Description
    LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).
  • Description
    LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mice implanted with 92.1 GNAQ mutant uveal melanoma cells.Dosage:15, 30, 75, 150 mg/kg Administration:P.O. (bid) for 35 days Result:Dose-dependently suppressed the tumor growth.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC
  • Research Area
    Cancer
  • Indication
    Colorectal Cancer; Malignant melanoma; Solid tumours; Uveal melanoma

Chemical Information

  • CAS Number
    1874276-76-2
  • Formula Weight
    472.47
  • Molecular Formula
    C22H23F3N8O?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (211.65 mM)
  • SMILES
    CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Protein Kinase C Inhibitor LXS196.
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