IC-9564 ( IC9564;AIDS033640 )

Catalog No. M12649 CAS No. 174847-98-4

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

IC-9564
Note

Research use only, not for human use.
Brief Description

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor.
Description

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain; also has IC90s of >5, 2.65, and 1.84 uM for DH012, QZ4734, and HIV-1 89.6, respectively; HIV-1 gp120 plays a key role in the anti-HIV-1 activity of IC9564.
Synonyms

IC9564;AIDS033640
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

——
Indication

——

Chemical Information

CAS Number

174847-98-4
Formula Weight

755.14
Molecular Formula

C46H78N2O6
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)CC(C(CC(=O)O)O)NC(=O)CCCCCCCNC(=O)C12CCC(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=C)C
Chemical Name

(3R,4S)-3-Hydroxy-4-[[8-[[(3β)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino]-1-oxooctyl]amino]-6-methylheptanoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Holz-Smith SL, et al. Antimicrob Agents Chemother. 2001 Jan;45(1):60-6.
2. Narumi T, et al. Bioorg Med Chem. 2013 May 1;21(9):2518-26.
3. Sun IC, et al. J Med Chem. 2002 Sep 12;45(19):4271-5.

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