IC-9564

CAS No. 174847-98-4

IC-9564 ( IC9564;AIDS033640 )

Catalog No. M12649 CAS No. 174847-98-4

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IC-9564
  • Note
    Research use only, not for human use.
  • Brief Description
    IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor.
  • Description
    IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain; also has IC90s of >5, 2.65, and 1.84 uM for DH012, QZ4734, and HIV-1 89.6, respectively; HIV-1 gp120 plays a key role in the anti-HIV-1 activity of IC9564.
  • Synonyms
    IC9564;AIDS033640
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    174847-98-4
  • Formula Weight
    755.14
  • Molecular Formula
    C46H78N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)CC(C(CC(=O)O)O)NC(=O)CCCCCCCNC(=O)C12CCC(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=C)C
  • Chemical Name
    (3R,4S)-3-Hydroxy-4-[[8-[[(3β)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino]-1-oxooctyl]amino]-6-methylheptanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Holz-Smith SL, et al. Antimicrob Agents Chemother. 2001 Jan;45(1):60-6.
2. Narumi T, et al. Bioorg Med Chem. 2013 May 1;21(9):2518-26.
3. Sun IC, et al. J Med Chem. 2002 Sep 12;45(19):4271-5.
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