LY3023414

Research use only, not for human use.

LY3023414 is a potent, dual PI3K/mTOR inhibitor.

LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively; inhibits the phosphorylation of AKT at position T308 with IC50 of 106 nM in the PTEN-deficient U87 MG glioblastoma cell line, inhibits phosphorylation of AKT at position S473 (IC50=94.2 nM) by mTORC2 as well as phosphorylation of mTORC1 kinase targets p70S6K (position T389; IC50=10.6 nM); causes G1 cell-cycle arrest and shows broad antiproliferative activity in cancer cell panel screens; exhibits antitumor activity in multiple xenograft models.Lung Cancer Phase 2 Clinical

LY-3023414;LY 3023414

PI3K/Akt/mTOR signaling

PI3K

classIPI3Kisoforms;DNA-PK;mTORkinase

Cancer

Lung Cancer

1386874-06-1

406.48

C23H26N4O3

>98% (HPLC)

10 mM in DMSO

O=C(N1C[C@@H](OC)C)N(C)C2=C1C3=CC(C4=CC(C(C)(O)C)=CN=C4)=CC=C3N=C2

2H-Imidazo[4,5-c]quinolin-2-one, 1,3-dihydro-8-[5-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(2S)-2-methoxypropyl]-3-methyl-

(-20℃)

With Ice Pack

≥ 2 years