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IAA-94

CAS No. 54197-31-8

IAA-94( IAA94 )

Catalog No. M14941 CAS No. 54197-31-8

IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IAA-94
  • Note
    Research use only, not for human use.
  • Brief Description
    IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.
  • Description
    IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM; significantly suppresses IGF-I-induced VSMC proliferation, also blocks cell swelling evoked glutamate release from primary microglia and MLS-9 cells; effectively reduces IFNgamma-induced NO production in microglial BV2 cells.
  • In Vitro
    IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins.
  • In Vivo
    ——
  • Synonyms
    IAA94
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    54197-31-8
  • Formula Weight
    357.2284
  • Molecular Formula
    C17H18Cl2O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3
  • Chemical Name
    Acetic acid, 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Landry DW, et al. J Gen Physiol. 1987 Dec;90(6):779-98. 2. Cheng G, et al. Cardiovasc Res. 2007 Jan 1;73(1):198-207. 3. Schlichter LC, et al. Channels (Austin). 2011 Mar-Apr;5(2):128-37. 4. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.
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