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I-152
CAS No. 311343-11-0
I-152( —— )
Catalog No. M36625 CAS No. 311343-11-0
I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 119 | Get Quote |
|
| 5MG | 200 | Get Quote |
|
| 10MG | 342 | Get Quote |
|
| 25MG | 569 | Get Quote |
|
| 50MG | 914 | Get Quote |
|
| 100MG | 1431 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameI-152
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NoteResearch use only, not for human use.
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Brief DescriptionI-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .
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DescriptionI-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties.
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In VitroWestern Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.062, 0.125, 0.25, 1, 5 or 10 mM.Incubation Time:2 h or 24 h.Result:Reduced the expression of NRF2/β-ACTIN, increased the expression of GCLM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number311343-11-0
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Formula Weight264.36
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Molecular FormulaC9H16N2O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (378.27 mM; Ultrasonic )
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SMILES[C@H](C(NCCSC(C)=O)=O)(NC(C)=O)CS
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175. ?
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