Homoharringtonine ( NSC 141633; Omacetaxine Mepesuccinate )

Catalog No. M13820 CAS No. 26833-87-4

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Product Name

Homoharringtonine
Note

Research use only, not for human use.
Brief Description

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies.
Description

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome . Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities, may have the potential ability to treat acute, chronic myeloid leukaemia and Gefitinib-resistant NSCLC.
Synonyms

NSC 141633; Omacetaxine Mepesuccinate
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT3
Research Area

Cancer
Indication

——

CAS Number

26833-87-4
Formula Weight

545.61
Molecular Formula

C29H39NO9
Purity

>98%(HPLC)
Solubility

Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
SMILES

COC1=C[C@@]23[C@H](c4cc(OCO5)c5cc4CCN2CCC3)[C@@H]1OC([C@](O)(CCCC(C)(C)O)CC(OC)=O)=O
Chemical Name

(S)-1-((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)succinate

1.Jin J, et al. Lancet Oncol. 2013 Jun;14(7):599-608.

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