Homoeriodictyol

CAS No. 446-71-9

Homoeriodictyol ( —— )

Catalog No. M22913 CAS No. 446-71-9

Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Homoeriodictyol
  • Note
    Research use only, not for human use.
  • Brief Description
    Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM.
  • Description
    Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT). In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D-(+)-glucose, treatment with 100 μM Homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM Homoeriodictyol to human neural SH-SY5Y cells.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    GLUT;5-HT Receptor;Sodium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    446-71-9
  • Formula Weight
    302.28
  • Molecular Formula
    C16H14O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C[C@@H](C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells.PLoS One. 2017 Feb 13;12(2):e0171580.
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