Tropisetron
CAS No. 89565-68-4
Tropisetron ( ICS 205-930; Tropisetronum; Tropisteron )
Catalog No. M27585 CAS No. 89565-68-4
Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 35 | In Stock |
|
25MG | 65 | In Stock |
|
50MG | 115 | In Stock |
|
100MG | 178 | In Stock |
|
500MG | 462 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameTropisetron
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NoteResearch use only, not for human use.
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Brief DescriptionTropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
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DescriptionTropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.
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SynonymsICS 205-930; Tropisetronum; Tropisteron
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorTRPM8
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Research Area——
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Indication——
Chemical Information
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CAS Number89565-68-4
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Formula Weight284.4
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Molecular FormulaC17H20N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.
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