Tropisetron

CAS No. 89565-68-4

Tropisetron ( ICS 205-930; Tropisetronum; Tropisteron )

Catalog No. M27585 CAS No. 89565-68-4

Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 35 In Stock
25MG 65 In Stock
50MG 115 In Stock
100MG 178 In Stock
500MG 462 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Tropisetron
  • Note
    Research use only, not for human use.
  • Brief Description
    Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
  • Description
    Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.
  • Synonyms
    ICS 205-930; Tropisetronum; Tropisteron
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    TRPM8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    89565-68-4
  • Formula Weight
    284.4
  • Molecular Formula
    C17H20N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.
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