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Homo-VK-II-36

CAS No. 1479049-35-8

Homo-VK-II-36 ( Homo VK II 36; HomoVKII36; Homo-V-II-36 )

Catalog No. M23634 CAS No. 1479049-35-8

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Homo-VK-II-36
  • Note
    Research use only, not for human use.
  • Brief Description
    Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.
  • Description
    Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.
  • Synonyms
    Homo VK II 36; HomoVKII36; Homo-V-II-36
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RyR2 channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1479049-35-8
  • Formula Weight
    460.5
  • Molecular Formula
    C27H28N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    COC1=CC=CC=C1OCCN2CC(OCC2=O)CCOC3=CC=CC4=C3C5=CC=CC=C5N4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197.
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