Homo-VK-II-36 ( Homo VK II 36; HomoVKII36; Homo-V-II-36 )

Catalog No. M23634 CAS No. 1479049-35-8

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Homo-VK-II-36
Note

Research use only, not for human use.
Brief Description

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.
Description

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-?overload-induced calcium release through the RyR2 channel.
Synonyms

Homo VK II 36; HomoVKII36; Homo-V-II-36
Pathway

Others
Target

Other Targets
Recptor

RyR2 channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1479049-35-8
Formula Weight

460.5
Molecular Formula

C27H28N2O5
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

COC1=CC=CC=C1OCCN2CC(OCC2=O)CCOC3=CC=CC4=C3C5=CC=CC=C5N4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197.

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