MAC-545496
CAS No. 838810-96-1
MAC-545496 ( —— )
Catalog No. M21764 CAS No. 838810-96-1
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMAC-545496
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NoteResearch use only, not for human use.
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Brief DescriptionMAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM).
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DescriptionMAC-545496 potently synergizes with Cefuroxime; concentrations as low as 0.03 μg/mL (~75 nM) lowers the β-lactam MIC from 512 to 8 μg/mL against S. aureus USA300. MAC545496 also synergizes with Cefuroxime and Oxacillin against a collection of ten S. aureus clinical isolates. In addition, MAC-545496 potentiates the effect of Cefuroxime against representatives of other circulating MRSA strains such as USA100, USA400 and USA500 to different extents, with the exception of CMRSA4, a USA200/EMRSA16 isolate. MAC-545496 also synergizes with the antimicrobial peptides colistin and polymyxin B.MAC-545496 shows inhibition of mprF expression in a concentration-dependent manner; the IC50 value is 0.0376 μg/mL.MAC-545496 also inhibits the citrateinduced biofilm formation in the wild type in a concentration dependent manner.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAntibacterial
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number838810-96-1
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Formula Weight419.89
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Molecular FormulaC18H18ClN5O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 250 mg/mL (595.39 mM; Need ultrasonic)
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SMILESO=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.
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