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Home - Products - Nuclear Receptor/Transcription Factor - eIF - Hippuristanol

Hippuristanol

CAS No. 80442-78-0

Hippuristanol( Hippuristanol )

Catalog No. M16010 CAS No. 80442-78-0

Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hippuristanol
  • Note
    Research use only, not for human use.
  • Brief Description
    Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).
  • Description
    Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis; also reduces the expression of cyclin D2, CDK2, CDK4, CDK6 and prosurvival XIAP and Mcl-1 proteins; significantly inhibits the growth and invasion of PEL cells in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Hippuristanol
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    80442-78-0
  • Formula Weight
    462.66
  • Molecular Formula
    C28H46O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@]1(O[C@@](C[C@H](C)C2(C)C)(O2)[C@@]3(O)C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@H](O)CC[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]13[H]
  • Chemical Name
    (3R,5S,11S,20R,22S,24S)-24-Methyl-22,25-epoxyfurostan-3,11,20-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cencic R, et al. Translation (Austin). 2016 Jan 4;4(1):e1137381. 2. Somaiah R, et al. J Med Chem. 2014 Mar 27;57(6):2511-23. 3. Ishikawa C, et al. Mar Drugs. 2013 Sep 6;11(9):3410-24.
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