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4EGI-1
CAS No. 315706-13-9
4EGI-1( eIF4E/eIF4G Interaction Inhibitor )
Catalog No. M14029 CAS No. 315706-13-9
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 208 | In Stock |
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| 50MG | 332 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name4EGI-1
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NoteResearch use only, not for human use.
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Brief Description4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
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Description4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E); disrupts eIF4E/eIF4G association and inhibits cap-dependent translation; inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.
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In Vitro——
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In Vivo——
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SynonymseIF4E/eIF4G Interaction Inhibitor
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PathwayNuclear Receptor/Transcription Factor
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TargeteIF
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RecptoreIF-4E/eIF-4G
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number315706-13-9
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Formula Weight451.2833
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Molecular FormulaC18H12Cl2N4O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 35 mg/mL
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SMILESO=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
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Chemical NameBenzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Moerke NJ, et al. Cell. 2007 Jan 26;128(2):257-67.
2. Wang W, et al. Oncotarget. 2016 Apr 19;7(16):21728-41.
3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95.
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