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Herniarin

CAS No. 531-59-9

Herniarin( 7-Methoxycoumarin | Methyl umbelliferyl ether )

Catalog No. M18747 CAS No. 531-59-9

Herniarin is a natural coumarin with antitumor effect.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Herniarin
  • Note
    Research use only, not for human use.
  • Brief Description
    Herniarin is a natural coumarin with antitumor effect.
  • Description
    Herniarin is a natural coumarin with antitumor effect.(In Vitro):Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 μM. Herniarin (100 μM) also induces apoptosis in MCF-7 cells. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5?μg/mL cisplatin, Herniarin (80 μg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation.
  • In Vitro
    Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 μM. Herniarin (100 μM) also induces apoptosis in MCF-7 cells. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5?μg/mL cisplatin, Herniarin (80 μg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation.
  • In Vivo
    ——
  • Synonyms
    7-Methoxycoumarin | Methyl umbelliferyl ether
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    531-59-9
  • Formula Weight
    176.17
  • Molecular Formula
    C10H8O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL; 709.54 mM
  • SMILES
    COc1ccc2ccc(=O)oc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30.
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