Harpagoside

CAS No. 19210-12-9

Harpagoside ( SMR001233395; Eharpagoside )

Catalog No. M18178 CAS No. 19210-12-9

Harpagoside has anti-inflammatory activity at 3 mM concentration, shows moderate inhibition of seed germination.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 52 In Stock
10MG 82 In Stock
25MG 149 In Stock
50MG 221 In Stock
100MG 334 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Harpagoside
  • Note
    Research use only, not for human use.
  • Brief Description
    Harpagoside has anti-inflammatory activity at 3 mM concentration, shows moderate inhibition of seed germination.
  • Description
    Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil’s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.
  • Synonyms
    SMR001233395; Eharpagoside
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    19210-12-9
  • Formula Weight
    494.49
  • Molecular Formula
    C24H30O11
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4
  • Chemical Name
    [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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