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Home - Products - Membrane Transporter/Ion Channel - GAT - HZ-166

HZ-166

CAS No. 612527-56-7

HZ-166( HZ166 )

Catalog No. M15304 CAS No. 612527-56-7

HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    HZ-166
  • Note
    Research use only, not for human use.
  • Brief Description
    HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.
  • Description
    HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors; displays a statistically significant higher affinity for receptors not containing the α1 subunit with a rank order of α5 (Ki=140nM) > α2 (Ki=269 nM) > α1 (Ki=382 nM); The Ki value of HZ166 for the α3β3γ2 combination (185± 47 nM) was statistically significantly lower than the Ki value observed for α1β3γ2 but not different from those of α2β3γ2 and α5β3γ2; HZ-166 is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HZ166
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    612527-56-7
  • Formula Weight
    356.385
  • Molecular Formula
    C21H16N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=C2N(C=N1)C3=CC=C(C#C)C=C3C(C4=NC=CC=C4)=NC2)OCC
  • Chemical Name
    Ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fischer BD, et al. Neuropharmacology. 2010 Dec;59(7-8):612-8. 2. Di Lio A, et al. Neuropharmacology. 2011 Mar;60(4):626-32. 3. Witkin JM, et al. Neuropharmacology. 2018 Jul 15;137:332-343. 4. Rivas FM, et al. J Med Chem. 2009 Apr 9;52(7):1795-8.
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