HT-0712

Research use only, not for human use.

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3.

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A; facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells, abolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons.Alzheimer Disease Phase 2 Clinical

IPL-455903

Angiogenesis

PDE

PDE

Neurological Disease

Alzheimer Disease

617720-02-2

393.53

C25H31NO3

>98% (HPLC)

——

O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4

(3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one

(-20℃)

With Ice Pack

≥ 2 years