HT-0712

CAS No. 617720-02-2

HT-0712 ( IPL-455903 )

Catalog No. M15336 CAS No. 617720-02-2

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HT-0712
  • Note
    Research use only, not for human use.
  • Brief Description
    HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3.
  • Description
    HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A; facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells, abolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons.Alzheimer Disease Phase 2 Clinical
  • Synonyms
    IPL-455903
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    617720-02-2
  • Formula Weight
    393.53
  • Molecular Formula
    C25H31NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4
  • Chemical Name
    (3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Peters M, et al. Neuropsychopharmacology. 2014 Dec;39(13):2938-48.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22.
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