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Home - Products - GPCR/G Protein - LPA Receptor - HG-14-10-04

HG-14-10-04

CAS No. 1356962-34-9

HG-14-10-04( HG-14-10-04 )

Catalog No. M17255 CAS No. 1356962-34-9

HG-14-10-04 is a potent and specific ALK inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 113 In Stock
10MG 186 In Stock
25MG 266 In Stock
50MG 332 In Stock
100MG 478 In Stock
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Biological Information

  • Product Name
    HG-14-10-04
  • Note
    Research use only, not for human use.
  • Brief Description
    HG-14-10-04 is a potent and specific ALK inhibitor.
  • Description
    HG-14-10-04 is a novel potent and specific ALK inhibitor.
  • In Vitro
    HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM.HG-14-10-04 (compound 17b) exhibits kinase inhibitory activity against EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS with IC50s of 15.6 nM, 22.6 nM and 124.5 nM, respectively.
  • In Vivo
    ——
  • Synonyms
    HG-14-10-04
  • Pathway
    GPCR/G Protein
  • Target
    LPA Receptor
  • Recptor
    ALK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1356962-34-9
  • Formula Weight
    532.08
  • Molecular Formula
    C29H34ClN7O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 13.3 mg/mL. 25.00 mM;
  • SMILES
    CN1CCN(C2CCN(c3ccc(Nc4ncc(Cl)c(c5c[nH]c6c5cccc6)n4)c(OC)c3)CC2)CC1
  • Chemical Name
    [5-Chloro-4-(1H-indol-3-yl)-pyrimidin-2-yl]-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
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