Cart
sales@molnova.com
Home - Products - GPCR/G Protein - LPA Receptor - Ki16198

Ki16198

CAS No. 355025-13-7

Ki16198( —— )

Catalog No. M19446 CAS No. 355025-13-7

Ki16198 is the methyl ester of Ki16425 which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 72 Get Quote
10MG 125 Get Quote
25MG 260 Get Quote
50MG 410 Get Quote
100MG 605 Get Quote
500MG 1287 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Ki16198
  • Note
    Research use only, not for human use.
  • Brief Description
    Ki16198 is the methyl ester of Ki16425 which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM.
  • Description
    Ki16198 is the methyl ester of Ki16425 which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM respectively shows weaker inhibition for LPA2 no activity at LPA4 LPA5 LPA6.
  • In Vitro
    Ki16198 (0-10 μM; 48 hours) is effective to inhibit migration and invasion responses to LPA with a potency similar to that of Ki16425. The inhibitory effects Ki16198 on the invasion response to LPA, but not to EGF in several pancreatic cancer cell lines, including Panc-1,CFPAC-1, and BxPC-3 cells.Ki16198 (10 μM; 48 hours) signifivcantly decreases expression of proMMP-9 protein and mRNA expression in YAPC-PD cells.
  • In Vivo
    Ki16198 (oral administaion; 1 mg in 500 ul; 28 days) significantly decreases the degree of metastasis activity in Ki16198-treated mice. Similiar to liver, metastasis to lung and brain in mice is also observed. Animal Model:Male BALB/c nude mice (6 weeks old) Dosage:1 mg in 500 ul Administration:Oral administaion; 28 days Result:Inhibited lung and liver metastasis in vivo.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    LPA Receptor
  • Recptor
    LPA1 LPA3
  • Research Area
    Cancer
  • Indication
    Cancer

Chemical Information

  • CAS Number
    355025-13-7
  • Formula Weight
    488.98
  • Molecular Formula
    C24H25ClN2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:89 mg/mL (182 mM);Ethanol:33 mg/mL (67.5 mM);Water:<1 mg/mL
  • SMILES
    COC(=O)CCSCC1=CC=C(C=C1)C1=C(NC(=O)OC(C)C2=C(Cl)C=CC=C2)C(C)=NO1
  • Chemical Name
    3-(4-(4-((1-(2-Chlorophenyl)ethoxy)carbonylamino)-3-methyl-5-isoxazolyl)benzylsulfanyl)propanoic acid methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Komachi M et al. Cancer Sci 2012 103(6) 1099-1104.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Radioprotectin-1

    Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.

  • LPA1 receptor antago...

    LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.

  • TAK-615

    TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

Sign In Join Free