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HCI-2389
CAS No. ——
HCI-2389( HCI2389 )
Catalog No. M17077 CAS No. ——
A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHCI-2389
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.
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DescriptionA potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM; significantly decreases level of phosphorylated PP1-α in HeLa cellsat 10 nM, significantly increases the effectiveness of bortezomib in inhibiting proteasome activity at concentrations as low as 10?nM; inhibits the degradation of Cyclin B and Cdc2, successfully mitigates drug resistance in bortezomib-resistant multiple myeloma.
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In Vitro——
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In Vivo——
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SynonymsHCI2389
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PathwayCell Cycle/DNA Damage
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TargetHec1/Nek2
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RecptorHec1/Nek2
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight571.097
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Molecular FormulaC26H31ClN8O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(5-((5-chloro-4-((2-(N,N-dimethylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meng L, et al. Biomed Res Int. 2014;2014:273180.
molnova catalog
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