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HCI-2389

CAS No. ——

HCI-2389( HCI2389 )

Catalog No. M17077 CAS No. ——

A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HCI-2389
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.
  • Description
    A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM; significantly decreases level of phosphorylated PP1-α in HeLa cellsat 10 nM, significantly increases the effectiveness of bortezomib in inhibiting proteasome activity at concentrations as low as 10?nM; inhibits the degradation of Cyclin B and Cdc2, successfully mitigates drug resistance in bortezomib-resistant multiple myeloma.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HCI2389
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Hec1/Nek2
  • Recptor
    Hec1/Nek2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    571.097
  • Molecular Formula
    C26H31ClN8O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-(5-((5-chloro-4-((2-(N,N-dimethylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meng L, et al. Biomed Res Int. 2014;2014:273180.
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