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TAI-95
CAS No. 1438638-83-5
TAI-95( TAI95 )
Catalog No. M11861 CAS No. 1438638-83-5
TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTAI-95
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NoteResearch use only, not for human use.
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Brief DescriptionTAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
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DescriptionTAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines); demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity; induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp), also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.
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In Vitro——
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In Vivo——
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SynonymsTAI95
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PathwayCell Cycle/DNA Damage
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TargetHec1/Nek2
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RecptorHec1/Nek2
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Research Area——
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Indication——
Chemical Information
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CAS Number1438638-83-5
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Formula Weight493.6
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Molecular FormulaC24H23N5O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
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Chemical NameN-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30.
2. Huang LY, et al. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20.
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