TAI-95

CAS No. 1438638-83-5

TAI-95( TAI95 )

Catalog No. M11861 CAS No. 1438638-83-5

TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1413 Get Quote
50MG 2862 Get Quote
100MG 3870 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    TAI-95
  • Note
    Research use only, not for human use.
  • Brief Description
    TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
  • Description
    TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines); demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity; induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp), also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TAI95
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Hec1/Nek2
  • Recptor
    Hec1/Nek2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1438638-83-5
  • Formula Weight
    493.6
  • Molecular Formula
    C24H23N5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
  • Chemical Name
    N-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30. 2. Huang LY, et al. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20.
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