Cart
sales@molnova.com
TAI-95
CAS No. 1438638-83-5
TAI-95( TAI95 )
Catalog No. M11861 CAS No. 1438638-83-5
TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTAI-95
-
NoteResearch use only, not for human use.
-
Brief DescriptionTAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
-
DescriptionTAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines); demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity; induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp), also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.
-
In Vitro——
-
In Vivo——
-
SynonymsTAI95
-
PathwayCell Cycle/DNA Damage
-
TargetHec1/Nek2
-
RecptorHec1/Nek2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1438638-83-5
-
Formula Weight493.6
-
Molecular FormulaC24H23N5O3S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
-
Chemical NameN-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30.
2. Huang LY, et al. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20.
molnova catalog
related products
-
TAI-1
A potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.
-
INH154
INH154?is a novel small molecules disrupting Hec1/Nek2 interaction.
-
Nek2 inhibitor 3a
A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
