Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - DUB - HBX-19818

HBX-19818

CAS No. 1426944-49-1

HBX-19818 ( HBX19818; HBX-19818; HBX 19818 )

Catalog No. M11802 CAS No. 1426944-49-1

HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 71 Get Quote
5MG 115 Get Quote
10MG 178 Get Quote
25MG 312 Get Quote
50MG 464 Get Quote
100MG 672 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    HBX-19818
  • Note
    Research use only, not for human use.
  • Brief Description
    HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM.
  • Description
    HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM; exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
  • Synonyms
    HBX19818; HBX-19818; HBX 19818
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1426944-49-1
  • Formula Weight
    421.96
  • Molecular Formula
    C25H28ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 3.5 mg/mL; DMSO: 5.3 mg/mL (Need ultrasonic)
  • SMILES
    O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
  • Chemical Name
    2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • HBX 41108

    HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.

  • XL 188

    XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.

  • NSC632839

    A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.

Sign In Join Free