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Home - Products - Proteasome/Ubiquitin - DUB - HBX-19818

HBX-19818

CAS No. 1426944-49-1

HBX-19818( HBX19818 | HBX-19818 | HBX 19818 )

Catalog No. M11802 CAS No. 1426944-49-1

HBX-19818?is a?potent, selective USP7 inhibitor with IC50 of 28.1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HBX-19818
  • Note
    Research use only, not for human use.
  • Brief Description
    HBX-19818?is a?potent, selective USP7 inhibitor with IC50 of 28.1 uM.
  • Description
    HBX-19818?is a?potent, selective USP7 inhibitor with IC50 of 28.1 uM; exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HBX19818 | HBX-19818 | HBX 19818
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1426944-49-1
  • Formula Weight
    421.96
  • Molecular Formula
    C25H28ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 3.5 mg/mL; DMSO: 5.3 mg/mL (Need ultrasonic)
  • SMILES
    O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
  • Chemical Name
    2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
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