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H-1152

CAS No. 451462-58-1

H-1152( —— )

Catalog No. M20899 CAS No. 451462-58-1

H-1152 is a potent specific ATP-competitive and cell permeable ROCK inhibitor (Ki = 1.6 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    H-1152
  • Note
    Research use only, not for human use.
  • Brief Description
    H-1152 is a potent specific ATP-competitive and cell permeable ROCK inhibitor (Ki = 1.6 nM).
  • Description
    H-1152 is a potent specific ATP-competitive and cell permeable ROCK inhibitor (Ki = 1.6 nM).
  • In Vitro
    H-1152 is an inhibitor of Rho-kinase, with an IC50 of 12 nM for ROCK2. H-1152 (H-1152P) also shows less inhibitory activities against CaMKII, PKG, AuroraA, PKA, Src, PKC, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 0.180, 0.360, 0.745, 3.03, 3.06, 5.68, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively. H-1152 potently inhibits Rho kinase, with a Ki of 1.6 nM, and slightly suppresses PKA, PKC and MLCK, with Kis of?0.63, 9.27, and 10.1 μM, respectively. H-1152 (0.1-10 μM) highly inhibits MARCKS phosphorylation, with an IC50 value of 2.5 μM in LPA-treated cells, but shows no such obvious effects in PDBu-treated cells. H-1152 (0.5-10 μM) cuases no decreased neuronal survival. H-1152 (1, 5 or 10 μM) also exerts no alterations in the ratios of different neuronal morphologies. Furthermore, H-1152 (10 μM) increases neurite length in both BMP4 and LIF cultures.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    451462-58-1
  • Formula Weight
    319.42
  • Molecular Formula
    C16H21N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (313.07 mM)
  • SMILES
    Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12
  • Chemical Name
    4-Methyl-5-[[(2S)-2-methyl-14-diazepan-1-yl]sulfonyl]isoquinoline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ikenoya M Hidaka H Hosoya T et al. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152 a novel and specific Rho-kinase inhibitor [J]. Journal of Neurochemistry 2002 81(1):9-16.
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