Glycerol

CAS No. 56-81-5

Glycerol ( Glycerin )

Catalog No. M19631 CAS No. 56-81-5

Glycerol or glycerin is a colourless odourless viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Glycerol
  • Note
    Research use only not for human use.
  • Brief Description
    Glycerol or glycerin is a colourless odourless viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations.
  • Description
    Glycerol or glycerin is a colourless odourless viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations. Glycerol is an important component of triglycerides (i.e. fats and oils) and of phospholipids. Glycerol is a three-carbon substance that forms the backbone of fatty acids in fats. When the body uses stored fat as a source of energy glycerol and fatty acids are released into the bloodstream. The glycerol component can be converted into glucose by the liver and provides energy for cellular metabolism. Normally glycerol shows very little acute toxicity and very high oral doses or acute exposures can be tolerated. On the other hand chronically high levels of glycerol in the blood are associated with glycerol kinase deficiency (GKD). GKD causes the condition known as hyperglycerolemia an accumulation of glycerol in the blood and urine. There are three clinically distinct forms of GKD: infantile juvenile and adult. The infantile form is the most severe and is associated with vomiting lethargy severe developmental delay and adrenal insufficiency. The mechanisms of glycerol toxicity in infants are not known but it appears to shift metabolism towards chronic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding vomiting loss of appetite weak muscle tone (hypotonia) and lack of energy (lethargy). These can progress to heart liver and kidney abnormalities seizures coma and possibly death. These are also the characteristic symptoms of untreated GKD. Many affected children with organic acidemias experience intellectual disability or delayed development. Patients with the adult form of GKD generally have no symptoms and are often detected fortuitously.
  • Synonyms
    Glycerin
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite
  • Research Area
    Others
  • Indication
    Constipation cerebral edema

Chemical Information

  • CAS Number
    56-81-5
  • Formula Weight
    92.09
  • Molecular Formula
    C3H8O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:≥300 mg/mL (3257.68 mM);Water:>500mg/ml
  • SMILES
    OCC(O)CO
  • Chemical Name
    propane-123-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sweatman B C Farrant R D Holmes E et al. 600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances.[J]. Journal of Pharmaceutical & Biomedical Analysis 1993 11(8):651-64.
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