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Glutaminase-IN-1

CAS No. 2247127-79-1

Glutaminase-IN-1( —— )

Catalog No. M32940 CAS No. 2247127-79-1

Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine inhibitor of the renal-type glutaminase (KGA) variant, exhibited antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Glutaminase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine inhibitor of the renal-type glutaminase (KGA) variant, exhibited antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.
  • Description
    Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    transporter
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2247127-79-1
  • Formula Weight
    618.47
  • Molecular Formula
    C26H24F3N7O3Se
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (202.11 mM; Ultrasonic ) H2O : 2 mg/mL (3.23 mM; Ultrasonic (<60°C)
  • SMILES
    C(C(NC1=CC=C(CCCCC=2[Se]C(NC(CC3=CC=CC=N3)=O)=NN2)N=N1)=O)C4=CC(OC(F)(F)F)=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen Z, et al. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2018 Dec 13.?
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