Lidamidine

CAS No. 66871-56-5

Lidamidine ( Lidamidina; Lidamidinum )

Catalog No. M27821 CAS No. 66871-56-5

Lidamidine is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 393 Get Quote
10MG 581 Get Quote
25MG 888 Get Quote
50MG 1242 Get Quote
100MG 1674 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Lidamidine
  • Note
    Research use only, not for human use.
  • Brief Description
    Lidamidine is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.
  • Description
    Lidamidine is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.(In Vivo):Fasted male rats were anesthetised and equipped with an intraluminal cannula positioned at the proximal end of a 10 cm fluid-filled segment of the ascending colon (basal pressure, 10 cm H2O). Intraluminal pressure was monitored by a transducer attached to a closed fluid-filled system. All drugs were administered intravenously by slow infusion. A regular pattern of distinct contractile complexes was observed over a 70 min period. These contractions increased intraluminal pressure to 39 +/- 1.2 cm H2O (mean +/- S.E.), occurred at a frequency of 0.3 per min and lasted from 1 to 2.5 min. Inhibition of these contractile patterns was observed with either atropine (0.1 mg/kg) or lidamidine (3.0 mg/kg). A 20 min pretreatment with idazoxan (3.0 mg/kg) antagonized lidamidine's but not atropine's effect. Trimazosin (1 mg/kg) or propranolol (0.3 mg/kg) pretreatment did not antagonize the lidamidine-generated inhibition.
  • Synonyms
    Lidamidina; Lidamidinum
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    H1 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66871-56-5
  • Formula Weight
    220.3
  • Molecular Formula
    C11H16N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CNC(=N)NC(=O)Nc1c(C)cccc1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Towart R, et al. Investigation of the antihistaminic action of dimethindene maleate (Fenistil) and its optical isomers. Agents Actions Suppl. 1991;33:403-8.
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