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Home - Products - Cell Cycle/DNA Damage - DNA Alkylator - Glufosfamide

Glufosfamide

CAS No. 132682-98-5

Glufosfamide ( D-19575;D19575 )

Catalog No. M11306 CAS No. 132682-98-5

A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Glufosfamide
  • Note
    Research use only, not for human use.
  • Brief Description
    A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.
  • Description
    A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters; has the better cell permeability than ifosfamide; Glufosfamide utilizes the normal cell glucose transport mechanism (SAAT1) for transport into the cell, enhances the activity of gemcitabine in vitro and in vivo.Pancreatic Cancer Phase 3 Clinical
  • Synonyms
    D-19575;D19575
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA Alkylator
  • Research Area
    Cancer
  • Indication
    Pancreatic Cancer

Chemical Information

  • CAS Number
    132682-98-5
  • Formula Weight
    383.16
  • Molecular Formula
    C10H21Cl2N2O7P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=P(NCCCl)(NCCCl)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O
  • Chemical Name
    N,N'-Bis(2-chloroethyl)phosphorodiamidic acid beta-D-glucopyranosyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Veyhl M, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2914-9.
2. Styczynski J, et al. Anticancer Res. 2002 Jan-Feb;22(1A):247-50.
3. Seker H, et al. Br J Cancer. 2000 Feb;82(3):629-34.
4. Ammons WS, et al. Neoplasia. 2007 Aug;9(8):625-33.
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