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Glufosfamide
CAS No. 132682-98-5
Glufosfamide( D-19575 | D19575 )
Catalog No. M11306 CAS No. 132682-98-5
A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 239 | Get Quote |
|
| 50MG | 1251 | Get Quote |
|
| 100MG | 1971 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGlufosfamide
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NoteResearch use only, not for human use.
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Brief DescriptionA conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.
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DescriptionA conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters; has the better cell permeability than ifosfamide; Glufosfamide utilizes the normal cell glucose transport mechanism (SAAT1) for transport into the cell, enhances the activity of gemcitabine in vitro and in vivo.Pancreatic Cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsD-19575 | D19575
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PathwayCell Cycle/DNA Damage
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TargetDNA Alkylator
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RecptorDNA Alkylator
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number132682-98-5
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Formula Weight383.16
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Molecular FormulaC10H21Cl2N2O7P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 125 mg/mL (326.23 mM)
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SMILESO=P(NCCCl)(NCCCl)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O
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Chemical NameN,N'-Bis(2-chloroethyl)phosphorodiamidic acid beta-D-glucopyranosyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Veyhl M, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2914-9.
2. Styczynski J, et al. Anticancer Res. 2002 Jan-Feb;22(1A):247-50.
3. Seker H, et al. Br J Cancer. 2000 Feb;82(3):629-34.
4. Ammons WS, et al. Neoplasia. 2007 Aug;9(8):625-33.
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