Gliotoxin

Research use only, not for human use.

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.(In Vitro):Incubation of the cells for 10min with 30-100ng/ml of Gliotoxin inhibited phagocytosis of either zymosan or serum-opsonized zymosan without affecting superoxide production or the exocytosis of specific and azurophil granules. Gliotoxin exhibited anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50?values of <0.03 μM.

Aspergillin

Apoptosis

Apoptosis

Apoptosis

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67-99-2

326.4

C13H14N2O4S2

>98% (HPLC)

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CN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O

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(-20℃)

With Ice Pack

≥ 2 years