
Gliotoxin
CAS No. 67-99-2
Gliotoxin( Aspergillin )
Catalog No. M29154 CAS No. 67-99-2
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
Purity : >98% (HPLC)






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Biological Information
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Product NameGliotoxin
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NoteResearch use only, not for human use.
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Brief DescriptionGliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
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DescriptionGliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.(In Vitro):Incubation of the cells for 10min with 30-100ng/ml of Gliotoxin inhibited phagocytosis of either zymosan or serum-opsonized zymosan without affecting superoxide production or the exocytosis of specific and azurophil granules. Gliotoxin exhibited anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50?values of <0.03 μM.
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In Vitro——
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In Vivo——
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SynonymsAspergillin
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number67-99-2
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Formula Weight326.4
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Molecular FormulaC13H14N2O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMF : 5 mg/mL (15.32 mM)
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SMILESCN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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