Gliotoxin

CAS No. 67-99-2

Gliotoxin( Aspergillin )

Catalog No. M29154 CAS No. 67-99-2

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gliotoxin
  • Note
    Research use only, not for human use.
  • Brief Description
    Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
  • Description
    Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.(In Vitro):Incubation of the cells for 10min with 30-100ng/ml of Gliotoxin inhibited phagocytosis of either zymosan or serum-opsonized zymosan without affecting superoxide production or the exocytosis of specific and azurophil granules. Gliotoxin exhibited anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50?values of <0.03 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Aspergillin
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    67-99-2
  • Formula Weight
    326.4
  • Molecular Formula
    C13H14N2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMF : 5 mg/mL (15.32 mM)
  • SMILES
    CN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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