Geraniin

Research use only, not for human use.

Geraniin has a protective effect against OVX-induced rat osteoporosis.Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo.

Geraniin has a protective effect against OVX-induced rat osteoporosis. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo, is a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. Geraniin has anti-oxidant activity, induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells.

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Endocrinology/Hormones

Aromatase

Antioxidant

Others-Field

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60976-49-0

952.64

C41H28O27

>98% (HPLC)

DMSO : 100 mg/mL 104.97 mM;

C1C2C3C(C(C(O2)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C6=C5C7C(=CC(=O)C(C7(O)O)(O6)O)C(=O)O3)O)O)OC(=O)C8=CC(=C(C(=C8C9=C(C(=C(C=C9C(=O)O1)O)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years