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Gepirone

CAS No. 83928-76-1

Gepirone( —— )

Catalog No. M27191 CAS No. 83928-76-1

Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gepirone
  • Note
    Research use only, not for human use.
  • Brief Description
    Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.
  • Description
    Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Sprague-Dawley rats Dosage:0, 0.1, 0.3, 1 and 3 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.Animal Model:Male Sprague-Dawley ratsDosage:10, 15 mg/kg Administration:Subcutaneous injection (s.c.)Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    IDH1-R132C| IDH1-R132H
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    83928-76-1
  • Formula Weight
    359.474
  • Molecular Formula
    C19H29N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 33.33 mg/mL (92.72 )
  • SMILES
    CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
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