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Gepirone
CAS No. 83928-76-1
Gepirone( —— )
Catalog No. M27191 CAS No. 83928-76-1
Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | Get Quote |
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| 10MG | 75 | Get Quote |
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| 25MG | 128 | Get Quote |
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| 50MG | 193 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGepirone
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NoteResearch use only, not for human use.
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Brief DescriptionGepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.
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DescriptionGepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.
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In Vitro——
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In VivoAnimal Model:Sprague-Dawley rats Dosage:0, 0.1, 0.3, 1 and 3 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.Animal Model:Male Sprague-Dawley ratsDosage:10, 15 mg/kg Administration:Subcutaneous injection (s.c.)Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorIDH1-R132C| IDH1-R132H
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Research Area——
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Indication——
Chemical Information
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CAS Number83928-76-1
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Formula Weight359.474
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Molecular FormulaC19H29N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 33.33 mg/mL (92.72 )
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SMILESCC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
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