Gepirone

CAS No. 83928-76-1

Gepirone( —— )

Catalog No. M27191 CAS No. 83928-76-1

Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 55 Get Quote
10MG 75 Get Quote
25MG 128 Get Quote
50MG 193 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Gepirone
  • Note
    Research use only, not for human use.
  • Brief Description
    Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.
  • Description
    Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Sprague-Dawley rats Dosage:0, 0.1, 0.3, 1 and 3 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.Animal Model:Male Sprague-Dawley ratsDosage:10, 15 mg/kg Administration:Subcutaneous injection (s.c.)Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    IDH1-R132C| IDH1-R132H
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    83928-76-1
  • Formula Weight
    359.474
  • Molecular Formula
    C19H29N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 33.33 mg/mL (92.72 )
  • SMILES
    CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
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