Bemesetron

CAS No. 40796-97-2

Bemesetron ( MDL 72222; 3-TROPANYL-3,5-DICHLOROBENZOATE; TROPANYL 3,5-DICHLOROBENZOATE )

Catalog No. M26626 CAS No. 40796-97-2

Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 45 In Stock
25MG 58 In Stock
50MG 77 In Stock
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Biological Information

  • Product Name
    Bemesetron
  • Note
    Research use only, not for human use.
  • Brief Description
    Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
  • Description
    Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.(In Vitro):In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively.(In Vivo):In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol.
  • Synonyms
    MDL 72222; 3-TROPANYL-3,5-DICHLOROBENZOATE; TROPANYL 3,5-DICHLOROBENZOATE
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    NLRP3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40796-97-2
  • Formula Weight
    314.2
  • Molecular Formula
    C15H17Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.
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