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Bemesetron
CAS No. 40796-97-2
Bemesetron ( MDL 72222; 3-TROPANYL-3,5-DICHLOROBENZOATE; TROPANYL 3,5-DICHLOROBENZOATE )
Catalog No. M26626 CAS No. 40796-97-2
Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 45 | In Stock |
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| 25MG | 58 | In Stock |
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| 50MG | 77 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBemesetron
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NoteResearch use only, not for human use.
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Brief DescriptionBemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
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DescriptionBemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.(In Vitro):In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively.(In Vivo):In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol.
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SynonymsMDL 72222; 3-TROPANYL-3,5-DICHLOROBENZOATE; TROPANYL 3,5-DICHLOROBENZOATE
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorNLRP3
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Research Area——
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Indication——
Chemical Information
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CAS Number40796-97-2
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Formula Weight314.2
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Molecular FormulaC15H17Cl2NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.
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