Bemesetron

CAS No. 40796-97-2

Bemesetron( MDL 72222 | 3-TROPANYL-3,5-DICHLOROBENZOATE | TROPANYL 3,5-DICHLOROBENZOATE )

Catalog No. M26626 CAS No. 40796-97-2

Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 45 In Stock
25MG 58 In Stock
50MG 77 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Bemesetron
  • Note
    Research use only, not for human use.
  • Brief Description
    Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
  • Description
    Bemesetron is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.(In Vitro):In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively.(In Vivo):In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol.
  • In Vitro
    Blockade of 5-HT3 receptor with Bemesetron (MDL7222) reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Bemesetron (0.01, 0.1 and 1 μM, 15 hours) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease of MTT reduction showing 74.9±2.4 and 79.0 ±2.5% with 1 μM and 5 μM, respectively, which are maximal effects. Pretreatment (20 minutes) with Bemesetron (1 μM), Y25130 (5 μM) or MK-801 (10 μM) significantly, but not completely, inhibits the H2O2-induced elevation of [Ca2+]c. Bemesetron (1 μM, 15 hours) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity.Cell Viability Assay Cell Line:Primary cortical neuronal cells Concentration:0.01-1 μM Incubation Time:20 minutes (pretreatment); 15 hours (post-incubation)Result:Concentration-dependently reduced the H2O2-induced decrease of MTT reduction showing 74.9±2.4% with 1 μM, which was maximal effect.Western Blot Analysis Cell Line:Primary cortical neuronal cells Concentration:1 μM Incubation Time:15 hours Result:Blocked significantly the H2O2-induced increase of caspase-3 immunoreactivity.
  • In Vivo
    Bemesetron (0.1, 1 and 10 mg/kg; i.p.) is used in male adult albino mice. The lowest dose do not cause any significant change in catalepsy. However, Bemesetron (1 mg/kg) causes a significant reduction of catalepsy (from 90 min after Haloperidol), while 10 mg/kg significantly potentiates the phenomenon (from 60 min after Haloperidol). The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol. Animal Model:Male adult albino mice, weighing 26-36 g Dosage:0.1-10 mg/kg Administration:Intraperitoneally injected, 20 min (pretreatment) +180 min (treatment)Result:Reduced catalepsy significantly at a dose of 1 mg/kg, whilst 10 mg/kg potentiated the phenomenon and 0.1 mg/kg was found to be without effect.
  • Synonyms
    MDL 72222 | 3-TROPANYL-3,5-DICHLOROBENZOATE | TROPANYL 3,5-DICHLOROBENZOATE
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    NLRP3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40796-97-2
  • Formula Weight
    314.21
  • Molecular Formula
    C15H17Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2 mg/mL (6.37 mM)
  • SMILES
    CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.
molnova catalog
related products
  • Trimipramine maleate

    Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.

  • KW-2478

    KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.

  • Triflupromazine hydr...

    Triflupromazine hydrochloride is an antipsychotic medication, which are Dopamine D1/D2 receptor antagonists.